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🚨BREAKING: Lilly's oral GLP-1, orforglipron, hits its primary endpoint in the Phase 3 ACHIEVE-1 trial for type 2 diabetes. | Michael Albert MD

The SURPASS trials demonstrated that patients on tirzepatide achieved significantly greater weight reduction compared to placebo by month 2, and continued progressive loss through 52 weeks

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So I'm certainly concerned about daily activity, frailty, falling, fractures, and so forth